| # | Giocatore | Squadra | P | Marcatori |
|---|---|---|---|---|
| 1 |  L. Messi |  Club Internacional de Fútbol Miami | 28 | 25 (1) |
| 2 |  P. Musa |  FC Dallas | 27 | 22 (5) |
| 3 |  M. Iloski |  Philadelphia Union | 31 | 19 (5) |
| 4 |  D. Bouanga |  Los Angeles Football Club | 30 | 18 (1) |
| 5 |  S. Surridge |  Nashville Soccer Club | 25 | 18 (3) |
| 6 |  Rafael Navarro |  Saint Louis City SC | 31 | 18 (4) |
| 7 |  B. White |  Vancouver Whitecaps Football Club | 29 | 17 (1) |
| 8 |  K. Yeboah |  Minnesota United FC | 30 | 17 (3) |
| 9 |  K. Denkey |  Football Club Cincinnati | 29 | 17 (3) |
| 10 |  H. Mukhtar | Nashville Soccer Club | 31 | 16 |
| 11 |  P. Judd |  San Jose Earthquakes | 28 | 16 |
| 12 |  Guilherme |  Houston Dynamo | 30 | 16 (1) |
| 13 |  M. Ojeda |  Orlando City Soccer Club | 25 | 16 (5) |
| 14 |  T. Baribo |  D.C. United | 25 | 16 (5) |
| 15 |  N. Fernández Mercau |  New York City FC | 30 | 15 (4) |
| 16 |  P. Owusu |  Club de Foot Montréal | 26 | 15 (6) |
| 17 |  I. Toklomati Giorno |  Charlotte Football Club | 30 | 14 |
| 18 |  S. Solans |  Real Salt Lake | 29 | 14 |
| 19 |  L. Suárez | Club Internacional de Fútbol Miami | 27 | 14 (2) |
| 20 |  A. Griezmann | Orlando City Soccer Club | 15 | 13 |
| # | Giocatore | Squadra | P | Assist |
|---|---|---|---|---|
| 1 | L. Messi | Club Internacional de Fútbol Miami | 28 | 12 |
| 2 |  A. Dreyer |  San Diego FC | 30 | 12 |
| 3 |  Son Heung-Min | Los Angeles Football Club | 29 | 12 |
| 4 |  C. Espinoza | Nashville Soccer Club | 27 | 12 |
| 5 |  A. Rusnák |  Seattle Sounders FC | 30 | 11 |
| 6 |  J. Pereyra | Minnesota United FC | 29 | 11 |
| 7 |  Evander | Football Club Cincinnati | 28 | 10 |
| 8 |  A. Ojeda | New York City FC | 31 | 10 |
| 9 |  M. Reus |  Los Angeles Galaxy | 29 | 9 |
| 10 |  R. De Paul | Club Internacional de Fútbol Miami | 26 | 9 |
| 11 |  J. Valiente | FC Dallas | 29 | 9 |
| 12 |  Justin Ellis | Orlando City Soccer Club | 22 | 9 |
| 13 | Guilherme | Houston Dynamo | 30 | 8 |
| 14 |  P. Aaronson |  Colorado Rapids | 31 | 8 |
| 15 |  P. Zinckernagel |  Chicago Fire FC | 30 | 8 |
| 16 |  T. Segovia | Club Internacional de Fútbol Miami | 27 | 8 |
| 17 |  F. Westfield | Philadelphia Union | 26 | 8 |
| 18 | H. Mukhtar | Nashville Soccer Club | 31 | 7 |
| 19 |  Pep Biel | Charlotte Football Club | 31 | 7 |
| 20 |  D. Turgeman |  New England Revolution | 30 | 7 |
| # | Giocatore | Squadra | P | Ammonizioni |
|---|---|---|---|---|
| 1 |  C. Durkin | Saint Louis City SC | 27 | 11 |
| 2 |  A. Westwood | Charlotte Football Club | 28 | 10 |
| 3 |  J. Díaz | Minnesota United FC | 28 | 10 |
| 4 |  B. Raines | New England Revolution | 28 | 10 |
| 5 |  J. Atencio | Colorado Rapids | 27 | 10 |
| 6 |  T. Jacob |  Atlanta United FC | 27 | 10 |
| 7 |  T. D'Avilla | Chicago Fire FC | 29 | 9 |
| 8 | P. Judd | San Jose Earthquakes | 28 | 9 |
| 9 |  R. Donkor |  New York Red Bulls | 28 | 9 |
| 10 | T. Segovia | Club Internacional de Fútbol Miami | 27 | 9 |
| 11 |  É. Ocampo | Vancouver Whitecaps Football Club | 27 | 9 |
| 12 |  R. Roberts | San Jose Earthquakes | 27 | 9 |
| 13 | N. Fernández Mercau | New York City FC | 30 | 8 |
| 14 |  H. Ojediran | Colorado Rapids | 28 | 8 |
| 15 |  Bryan Josías Ramírez León | Football Club Cincinnati | 27 | 8 |
| 16 |  A. Cubas | Vancouver Whitecaps Football Club | 25 | 8 |
| 17 |  E. Atuesta | Orlando City Soccer Club | 24 | 8 |
| 18 |  H. Dotson | Seattle Sounders FC | 22 | 8 |
| 19 |  D. Yedlin | Real Salt Lake | 22 | 8 |
| 20 |  Felipe Andrade | Houston Dynamo | 22 | 8 |
| # | Giocatore | Squadra | P | Espulsioni |
|---|---|---|---|---|
| 1 |  R. Holding | Colorado Rapids | 28 | 2 |
| 2 |  Y. Bright | Club Internacional de Fútbol Miami | 24 | 2 |
| 3 |  G. Valenzuela | Football Club Cincinnati | 26 | 2 |
| 4 |  C. Garcés | Los Angeles Galaxy | 20 | 1 |
| 5 |  Guilherme Biro |  Austin FC | 26 | 1 |
| 6 |  O. Nwobodo | Football Club Cincinnati | 25 | 1 |
| 7 |  M. Guilavogui | Real Salt Lake | 25 | 1 |
| 8 |  B. Vera | Club de Foot Montréal | 24 | 1 |
| 9 |  T. Blackmon | Vancouver Whitecaps Football Club | 29 | 1 |
| 10 |  A. Bouzat | Houston Dynamo | 26 | 1 |
| 11 |  W. Zimmerman |  Toronto FC | 22 | 1 |
| 12 |  J. Sery Larsen | Philadelphia Union | 14 | 1 |
| 13 |  J. Fory |  Portland Timbers | 29 | 1 |
| 14 |  K. Miller | Portland Timbers | 26 | 1 |
| 15 |  E. Mihaj | Atlanta United FC | 23 | 1 |
| 16 |  Samuel Sarver | FC Dallas | 19 | 1 |
| 17 |  W. Frederick II | Colorado Rapids | 27 | 1 |
| 18 |  J. Dean | Chicago Fire FC | 26 | 1 |
| 19 |  K. Agyabeng |  Sporting Kansas City | 22 | 1 |
| 20 |  J. Travis | Colorado Rapids | 16 | 1 |