Eastern Conference
| # | Squadra | G | V | N | P | GF | GS | DR | Pt | Forma |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Nashville Soccer Club | 30 | 20 | 7 | 3 | 64 | 23 | +41 | 67 | DWWWW |
| 2 |  Club Internacional de Fútbol Miami | 30 | 15 | 10 | 5 | 73 | 51 | +22 | 55 | WWWLD |
| 3 |  New England Revolution | 30 | 16 | 4 | 10 | 49 | 41 | +8 | 52 | WWLLW |
| 4 |  Chicago Fire FC | 30 | 14 | 6 | 10 | 52 | 44 | +8 | 48 | LLWWW |
| 5 |  Charlotte Football Club | 30 | 13 | 8 | 9 | 53 | 45 | +8 | 47 | DLWLW |
| 6 |  Philadelphia Union | 30 | 13 | 7 | 10 | 61 | 48 | +13 | 46 | DWWWW |
| 7 |  Orlando City Soccer Club | 30 | 12 | 5 | 13 | 58 | 70 | -12 | 41 | WDWLL |
| 8 |  New York Red Bulls | 30 | 10 | 6 | 14 | 39 | 56 | -17 | 36 | LLWLW |
| 9 |  Football Club Cincinnati | 28 | 9 | 9 | 10 | 60 | 68 | -8 | 36 | LWLDD |
| 10 |  Toronto FC | 30 | 8 | 12 | 10 | 46 | 55 | -9 | 36 | WDWLL |
| 11 |  New York City FC | 30 | 8 | 10 | 12 | 43 | 41 | +2 | 34 | DLLDL |
| 12 |  D.C. United | 29 | 7 | 12 | 10 | 37 | 51 | -14 | 33 | LWLDL |
| 13 |  Columbus Crew | 29 | 9 | 5 | 15 | 44 | 47 | -3 | 32 | WLWWL |
| 14 |  Atlanta United FC | 30 | 8 | 6 | 16 | 37 | 51 | -14 | 30 | LWLDW |
| 15 |  Club de Foot Montréal | 30 | 6 | 7 | 17 | 36 | 60 | -24 | 25 | DLLWL |
Western Conference
| # | Squadra | G | V | N | P | GF | GS | DR | Pt | Forma |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Vancouver Whitecaps Football Club | 30 | 16 | 7 | 7 | 63 | 31 | +32 | 55 | WDDLD |
| 2 |  Saint Louis City SC | 30 | 14 | 9 | 7 | 56 | 41 | +15 | 51 | LDWWW |
| 3 |  FC Dallas | 30 | 14 | 9 | 7 | 55 | 47 | +8 | 51 | DWLWD |
| 4 |  San Jose Earthquakes | 30 | 13 | 9 | 8 | 52 | 42 | +10 | 48 | DDDWD |
| 5 |  Houston Dynamo | 30 | 13 | 8 | 9 | 41 | 39 | +2 | 47 | DDDLD |
| 6 |  Los Angeles Football Club | 31 | 12 | 10 | 9 | 48 | 33 | +15 | 46 | DWDLD |
| 7 |  Seattle Sounders FC | 30 | 11 | 9 | 10 | 39 | 37 | +2 | 42 | DLWWW |
| 8 |  Los Angeles Galaxy | 31 | 10 | 10 | 11 | 43 | 52 | -9 | 40 | DWLWW |
| 9 |  Colorado Rapids | 30 | 11 | 6 | 13 | 41 | 41 | 0 | 39 | DDDLD |
| 10 |  Real Salt Lake | 30 | 10 | 6 | 14 | 45 | 48 | -3 | 36 | WDLWL |
| 11 |  Portland Timbers | 30 | 9 | 7 | 14 | 51 | 56 | -5 | 34 | DLDLL |
| 12 |  San Diego FC | 30 | 8 | 10 | 12 | 53 | 56 | -3 | 34 | DDLDD |
| 13 |  Minnesota United FC | 30 | 8 | 10 | 12 | 47 | 55 | -8 | 34 | WDDLL |
| 14 |  Austin FC | 30 | 7 | 10 | 13 | 38 | 56 | -18 | 31 | LLLDD |
| 15 |  Sporting Kansas City | 30 | 6 | 4 | 20 | 36 | 75 | -39 | 22 | LLDLW |